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Abstract

VALIDATED ANALYTICAL METHOD DEVELOPMENT FOR THE DETERMINATION OF MELOXICAM BY UV SPECTROSCOPY IN API AND PHARMACEUTICAL DOSAGE FORM

Meenu Chaudhary*, Kiran Bhardwaj, Govinda Verma, Praveen Kumar

Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology & Sciences, Dehradun, Uttarakhand, India - 248001.

ABSTRACT

A simple, precise and specific spectroscopy method for quantitative estimation of Meloxicam in API and in pharmaceutical dosage form was developed and validated. Meloxicam showed maximum absorbance at 365 nm by using ethanol as a solvent. The linear calibration curve obeys Beer-Lambert’s law in the concentration range of (2-18µg/ml) with regression equation of curve was y=0.050x-0.005 and the correlation coefficient was found to be (R2=0.997). Validation of this method was done and applied to the estimation of Meloxicam in pharmaceutical dosage form, no interference was found in the absorbance of the drug in the presence of the common excipients and analysis conditions.

Keywords: UV Spectroscopy, Calibration curve method, Analytical Method, Validation, Meloxicam


[Full Text Article]