SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL ANALGESIC AND ANTIINFLAMATORY ACTIVITY OF ACETOPHENONE DERIVATIVES
Dr. Rashmi Kumari 1*, Dr. S.K. Mishra2, Dr.Vachaspati Dubey3, Ruchi Singh4
*1,3,4Narayan Institute of Pharmacy, Sasaram Jamuhar, Bihar, India.
2Department of Pharmaceutical Engg. Technology (IIT) BHU, Varanasi, India.
A novel series of mannich bases of substituted acetophenone derivatives were synthesized. These compounds were identified on the basis of melting point range, Rf values, elemental analysis, IR and 1H NMR spectral analysis. The compounds were evaluated for antimicrobial, analgesic and antiinflammatory activities. All compounds exhibited significant to moderate biological activity.
Keywords: Mannich base, Acetophenone, antimicrobial, analgesic, anti-inflammatory activity.
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