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  • October 2018 issue published
  • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 7, Issue 4 (October Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Call for Article for January Issue
  • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 25 December, 2018 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • AJPER Impact facor
  • It is to pleasure that Ajper SJIF imact facor has increse from 4.101 to 5.019. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
  • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL ANALGESIC AND ANTIINFLAMATORY ACTIVITY OF ACETOPHENONE DERIVATIVES

Dr. Rashmi Kumari 1*, Dr. S.K. Mishra2, Dr.Vachaspati Dubey3, Ruchi Singh4

*1,3,4Narayan Institute of Pharmacy, Sasaram Jamuhar, Bihar, India.

2Department of Pharmaceutical Engg. Technology (IIT) BHU, Varanasi, India. 

 

ABSTRACT

A novel series of mannich bases of substituted acetophenone derivatives were synthesized. These compounds were identified on the basis of melting point range, Rf values, elemental analysis, IR and 1H NMR spectral analysis. The compounds were evaluated for antimicrobial, analgesic and antiinflammatory activities. All compounds exhibited significant to moderate biological activity.

Keywords: Mannich base, Acetophenone, antimicrobial, analgesic, anti-inflammatory activity.


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