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Abstract

DEVELOPMENT, SYNTHESIS AND ASSESSMENT OF ANTI-INFLAMMATORY ACTIVITY OF CHROMONES DERIVATIVES

Vishal Gupta1*, Gautam Girendra Kumar2 and S K Yadav3

1Research Scholar, Institute of Pharmaceutical science and research center, Bhagwant University, Ajmer, Rajasthan, India.

2Supervisor, Institute of Pharmaceutical science and research center, Bhagwant University, Ajmer, Rajasthan, India.

3Supervisor, Technocrat Institute of Technology –Pharmacy, Anand Nagar Bhopal (MP)

ABSTRACT

SnCl4 catalyzed Claisen rearrangement of allyl aryl ethers followed by cyclization gives oxygen hetrocycles. By utilizing SnCl4 as lewis acid the rearragment reaction is affected under mild condition The antiinflammatory activity of the synthesized compounds was determined by rat paw edema method. Some of the compounds were found to be potent.

Keywords: NSAID, Synthesized compounds, Antiinflammatory activity.


[Full Text Article]