Journal Front Page

News & Events

  • October 2018 issue published
  • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 7, Issue 4 (October Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Call for Article for January Issue
  • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 25 December, 2018 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • AJPER Impact facor
  • It is to pleasure that Ajper SJIF imact facor has increse from 4.101 to 5.019. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
  • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level



Vinod Dhote*, Kanika Dhote, Azaz Khan, H.S Chandel

Truba Institute of pharmacy, Bhopal (M.P)


The rationale of this study was to develop, optimize and characterize microsponge drug delivery system for antiviral delivery. Antiviral compound, emtricitabine was selected as a model drug. The microsponges were prepared by emulsion solvent diffusion method and optimize for various formulation parameters. The formulation (F1- F6) were characterized in terms of particle size, drug entrapment efficiency (DEE), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and zeta potential measurement. The drug release from the microsponge loaded gel was studied by modified Franz diffusion cell. F2 released 50.85% of drug at 8 hours. Diffusion exponent (n) value of F2 formulation was found to be 0.912 suggesting that the Ficks law of diffusion was not followed. The F2 formulation followed Zero order kinetics in its in vitro drug release. This study provides future insights for developing delayed release microsponge based gels for treatment of skin infections and disorders.

Keywords: Microsponge, Solvent diffusion method, Emtricitabine, Scanning electron microscopy, Differential scanning calorimetry.

[Full Text Article]