DEVELOPMENT & CHARACTERIZATION OF EMTRICITABINE LOADED MICROSPONGES
Vinod Dhote*, Kanika Dhote, Azaz Khan, H.S Chandel
Truba Institute of pharmacy, Bhopal (M.P)
The rationale of this study was to develop, optimize and characterize microsponge drug delivery system for antiviral delivery. Antiviral compound, emtricitabine was selected as a model drug. The microsponges were prepared by emulsion solvent diffusion method and optimize for various formulation parameters. The formulation (F1- F6) were characterized in terms of particle size, drug entrapment efficiency (DEE), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and zeta potential measurement. The drug release from the microsponge loaded gel was studied by modified Franz diffusion cell. F2 released 50.85% of drug at 8 hours. Diffusion exponent (n) value of F2 formulation was found to be 0.912 suggesting that the Ficks law of diffusion was not followed. The F2 formulation followed Zero order kinetics in its in vitro drug release. This study provides future insights for developing delayed release microsponge based gels for treatment of skin infections and disorders.
Keywords: Microsponge, Solvent diffusion method, Emtricitabine, Scanning electron microscopy, Differential scanning calorimetry.
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