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Abstract

DEVELOPMENT AND EVALUATION OF ORAL FILM OF HERBAL EXTRACTS OF PIPER BETEL AND FOENICULUM OFFICINALIS

Rajnish Kumar Verma1, Reenu Yadav*1, Anoop Singh1, Geeta Parkhe2, Dr. Yogesh Pounikar1

1Bhabha Pharmacy Research Institute, Bhopal(M.P.)

2Scan Research Laboratories, Bhopal (M.P.)

ABSTRACT

Oral dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules, etc. This work investigates the possibility of developing Piper betel and Foeniculum officinalis oral dissolving films allowing fast, reproducible dissolution in oral cavity; thus bypassing first pass metabolism. The oral dissolving films were prepared by solvent-casting method. HPMC for the formulation of the films is suitable polymer and plasticizers are selected. The films were subjected to physical investigations such as uniformity of weight, folding endurance, surface pH. Also evaluation of the films is done by using parameter like thickness, weight uniformity, folding endurance, percentage of moisture content, drug content analysis, disintegration time and in-vitro dissolution studies. The obtained results for prepared herbal films disintegrate within 1 minute. The formulation F-3 resulted into excellent palatability along with least disintegrating time and found to be stable when compared with other formulations. So, it was concluded that formulation F-3 is the best film forming as well as stable polymer with respect to Piper betel and Foeniculum officinalis oral dissolving film.

Keywords: Film-forming polymers, Oral thin films, Solvent-casting method, Piper betel, Foeniculum officinalis.


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