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Abstract

BIOACTIVE GUIDED FRACTIONATION OF PTEROSPERMUM ACERIFOLIUM FOR THE SCREENING OF NEUROCHEMICALS AND NEUROENDOCRINE EFFECTS

*Ankur Choubey, Ritu Gilhotra, Santosh Kumar Singh, Gopal Garg

Department of Pharmacognosy, School of Pharmacy, Suresh Gyan Vihar University, Jaipur

ABSTRACT

Pterospermum acerifolium is common plant in India is considered carminative, stimulant and emmenagogue. In the present study, ethanol extract of bark of Pterospermum acerifolium have been evaluated for Neurochemical study. Treatment with ethanolic extract of Pterospermum acerifolium was found to significantly decrease the serum levels of adrenocorticotropic hormone (ACTH), corticosterone (CORT) and -endorphin (-EP) as well as the brain and serum level of norepinephrine (NE). Furthermore, ethanolic extract of Pterospermum acerifolium was able to significantly reverse the chronic stress by decreasing the brain and serum levels of the monoamine neurotransmitters dopamine (DA), 5hydroxytryptamine (5-HT). The results obtained from this study suggested that the memory-enhancing effect of ethanolic extract of Pterospermum acerifolium was mediated through regulations of neurochemical and neuroendocrine systems. From the present study it was concluded that the herbal drugs can be potentially used to control the state of CNS disorders. Further investigations are, however, necessary to explore mechanism(s) of action involved in these pharmacological activities.

Keywords: Adrenocorticotropic, Corticosterone (CORT), Dopamine (DA), 5Hydroxytryptamine (5-HT)


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