Abstract

FAST DISSOLVING TABLET AND TASTE MASKING APPROACHES – AN OVERVIEW

D. B. Chaudhari^1*, S. S. Aher², R.B. Saudagar²

¹Department of Quality Assurance Techniques. R G Sapkal college of Pharmacy, Anjaneri, Nashik, Maharashtra, India.

² Department of Pharmaceutical Chemistry. R G Sapkal college of Pharmacy, Anjaneri, Nashik, Maharashtra, India.

ABSTRACT

Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. Particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, recent development in fast disintegrating technology mainly works to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the patented technologies available and the advances made so far in the field of fabrication of fast disintegrating tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique technologies like freeze drying, direct compression, spray drying, tablet molding, sublimation fast dissolving films cotton candy process, along with their advantages and limitations.

Keywords: Fast Dissolving Tablet, Patented Technology, Taste Masking Approaches, Superdisintigrant.