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Abstract

FORMULATION AND IN-VITRO EVALUATION OF ORAL HYDROGEL CONTAINING MICONAZOLE NITRATE

Umesh T. Jadhao*, Bharat W. Tekade, Rupesh Patil, Amol. P. Patil., Vijay R. Patil

TVES’s Honourable Loksevak Madhukarrao Chaudhary College of Pharmacy, Faizpur

ABSTRACT

The aim of the present work was to formulate and evaluate formulation of Miconazole nitrate as oral hydrogel to improve the efficacy & bioavailability of Miconazole nitrate. Miconazole Nitrate gel was prepared with Gellan gum and Carbopol 934P as gelling agents with polyethylene glycol as a penetration enhancer. The formulations were examined for pH, spreadability, consistency, viscosity, homogeneity, drug content and stability. In vitro drug release was evaluated using Franz diffusion cell. The viscosity of all formulation follows a pseudo-plastic flow behaviour. The pH of formulation Lies in between 6.3 to 7.2. The formulation C2 and G2 showed good released pattern. The formulation shown good resistance of bacterial growth as compared to the other formulation antifungal activity was more potent on fungal growth by the formulation G2 and C3.

Keywords: Miconazole nitrate, Gellan gum, antifungal, Rheology, in- vitro; Diffusion.


[Full Text Article]