PHYTOCHEMICAL SCREENING OF ETHANOLIC EXTRACT OF PREMNA CORIACEA THROUGH AN INTEGRATIVE GC-MS AND LC-MS
Karthikeyan M1*, Balasubramanian T2 and Pawan Kumar3
1Research Scholar, Department of Pharmacy and Medical Sciences, School of Pharmacy and Medical Sciences, Singhania University, Pacheribari, Jhunjhunu, Rajasthan, India-333 515
2Associate professor, Department of Pharmacology, Al Shifa College of Pharmacy, Kerala, India -679 325
3Associate Professor, Department of life Sciences, Singhania University, Pacheribari, Jhunjhunu, Rajasthan, India-333515.
Premna coriacea var. villosa is wood climber belongs to the family Lamiaceae. Premna genus plants have high medicinal importance in indian system of medicines to treat various diseases.The main objective of the present study is to analyse and find the phytoconstituents present in the leaves ethanolic extract of Premna coriacea. The Phytochemical analysis was done by standard procedure to find out the secondary metabolites, GCMS is carried out to find the volatile constituents and LCMS for non-volatile constituents. The preliminary phytochemical analysis confirms the presents of presence of Alkaloids, Carbohydrates, Glycosides, Steroids and Flavonoids. The GCMS analysis shows the presents of 68 compounds in which 23 have medicinal properties. The LCMS analysis shows the presents of 28 compounds in which most of them have the medicinal properties. The present phytochemical study on Premna coriacea ethanolic extract reveals the presence of phytoconstituents like Methyl Salicylate, hexadecanoic acid, Caryophyllene, Eugenol, Ledol, cis-Vaccenic acid, n-Hexadecanoic acid, Piperine, Phytol, Diethyl Phthalate etc. Premna coriacea could be a potential source for anti-inflammatory, analgesic, antimicrobial, antifungal and anticancer agents.
Keywords: Premna coriacea, Phytochemical analysis, LCMS, GCMS, Phytol, Ledol, Piperine
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