Abstract

FORMULATION DEVELOPMENT OF POLY HERBAL GEL FOR EFFECTIVE MANAGEMENT OF ACNE

Shailbala Singh Baghel*, Shweta Larya, Roshni Bhadouriya

Department of Chemistry, Sarojini Naidu Government Girls P.G. (Autonomous) College, Bhopal (M.P.)

ABSTRACT

Herbal remedies are more acceptable in the view that they are safe with fewer side effects than the synthetic ones. The present work deals with the development and evaluation of poly-herbal anti-acne formulation (gel) containing aqueous extract of Gloriosa superb flower and aqueous extract from bark of Litsea glutinosa. Aqueous extracts of Gloriosa superba and Litsea glutinosa were formulated in an aqueous based carbopol-934 gel system. Three formulations of the gel were prepared by varying the proportions of polymers and evaluated for their physicochemical properties like colour, consistency, washability, pH, spreadability and microbial assay. Based on these tests, formulation F-3 containing 1.5% carbopol-934 was selected as best formulation. The microbial assay of all the poly herbal formulations demonstrated better inhibitory activity against Propionibacterium acne and Staphylococcus epidermidis compared to the marketed clindamycin phosphate gel in equivalent amounts of application. It was concluded from the study that aqueous extract of Gloriosa superba and Litsea glutinosa can be formulated in an aqueous based gel system for topical therapy of mild acne vulgaris.

Keywords: Gloriosa superba, Antiacne, Litsea glutinosa, Gel, Topical