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Abstract

New Spectrophotometric Method for the Estimation of Lomefloxacin in Tablets using Sodium benzoate as Hydrotropic Agent

Arpana Gaur Mishra*

Department of Chemistry, Sarojini Naidu Government Girls P.G. (Autonomous) College,
Bhopal (M.P.)

ABSTRACT

A novel, safe and sensitive method of spectrophotometric estimation in ultraviolet region has been developed using 8.0 M Sodium benzoate solution as hydrotropic agent for the quantitative determination of lomefloxacin, a poorly water-soluble drug in tablet dosage form. Lomefloxacin shows maximum absorbance at 389 nm. Beer's law was obeyed in the concentration range of 10 to 50μg/ml, sodium benzoate does not absorb above 220nm. Commonly used tablet excipients and Sodium benzoate did not interfere in spectrophotometric estimation. Results of the analysis were validated statistically and by recovery studies. Using 8 M Sodium benzoate solution for analysis of tablet formulations of lomefloxacin, the percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent relative standard deviation.

Keywords: Lomefloxacin, hydrotropy, Sodium benzoate, spectrophotometry.


[Full Text Article]