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Abstract

VALIDATED SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF CLARITHROMYCIN IN MARKETED FORMULATION USING DYE DRUG REACTION

Alka Pradhan*

Department of Chemistry, Sarojini Naidu Government Girls P.G. (Autonomous) College,
Bhopal (M.P.)

ABSTRACT

Quality is important in every product or service, but it is vital in medicine, as it involves life, so there should not be any compromises to quality of drug product. In Present work a simple method developed for the estimation of clarithromycin in marketed formulation by spectrophotometer. The developed methods were found to be linear up to 10-50μg/ml. The values of mean percent recoveries were found to 99.12 to 99.44%. The mean percent label claims of tablets by the proposed methods were close to 100, indicating the accuracy of the proposed method and low values of standard deviation and percentage relative standard deviation was found to less than 2. The proposed Spectrophotometric methods were accurate, precise and reliable for the measurement of clarithromycin in dosage form.

Keywords: Spectrophotometric, Clarithromycin, Validation


[Full Text Article]