Login

Journal Front Page

News & Events

  • April 2024 Issue delayed
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, Volume 13, Issue 2 (April 2024) Issue) schedule published on 15 April 2024 is delay due to some technical problem. It will published on 22 April 2024. Sorry for inconvenience. For other details You can vist the website http://www.ajper.com
  • Call for article for April 2024 issue
    • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
    • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
    • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
    • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
    • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

PREPARATION AND EVALUATION OF BI-LAYER TABLETS OF PANTORAZOLE AND CLARITHROMYCIN

Nilesh Jain1, Prabhat Jain*2, Teena Parmar2, Geeta Parkhe2, Surendra Kumar Jain1

1Sagar Institute of research & technology, Bhopal (M.P.)
2Scan Research laboratories, Bhopal (M.P.)

ABSTRACT

The objective of the present investigation was to develop a Bi-layer floating tablet of Clarithromycin and Pantoprazole. it consists of two layers, The immediate release layer containing comprised super disintegrating agent and pantoprazole and floating SR layer containing HPMC of various grade as the release retarding polymers and Clarithromycin. Optimization of the best formulation among the nine formulations prepared for both IR and SR layer was done on the basis of their dsinrigation and dissolution profiles. IR layer tablets IF8 containing Crospovidone was found to be optimum of pantoprazole. The floating SR layer tablet of Clarithromycin (F6) containing HPMCK15M was found optimum. The Optimized immediate release (IF8) & sustained release (F6) formulation was combined and made into Bi-layer floating tablet. The optimised Bi-layer tablets of Clarithromycin and pantoprazole was formulated and evaluated for various evaluation parameters. All the results of evaluations was found to be within limits and the final Optimised Bi-layer formulation released up to 12hrs. This formulation are used for effective treatment of peptic ulcer.

Keywords: Clarithromycin, Pantoprazole; floating; H. pylori; peptic ulcer.


[Full Text Article]