Abstract

FORMULATION & DEVELOPMENT OF ACECLOFENAC AND OMEPRAZOLE SUSTAINED RELEASE MICROSPHERES

Bhavana kuraichaya, Dr. Jitendra Banweer*, Mr. Praveen Tahilani

Sagar Institute of Research, Technology & Science- Pharmacy (S.I.R.T.S.-P.), Bhopal

ABSTRACT

The purpose of this research was to develop and formulate combination of two drug aceclofenac and omeprazole in the form of sustained release microspheres having pH sensitivity property and microspheres were prepared by solvent-evaporation method using different drug polymer ratios (1:1 to1:3), stirring speeds (500-1000rpm), to prevent the side effect of aceclofenac the stomach and small intestine for this proton pump inhibitor omeprazole used. The prepared microspheres were characterized by percentage yield, particle size, entrapment efficiency, micromeritics properties, FTIR, in-vitro release behaviour, etc. The invitro release studies was performed by buffer change method to mimic gastro intestine tract (GIT) environment in pH 1.2, carbonate buffer (acidic) and pH 7.2, phosphate buffer (Alkaline). The infrared spectra showed stable character of aceclofenac omeprazole in the drug loaded microspheres and show the absence of drug polymer interactions. The drug loaded microspheres show high entrapment efficiency (74%) and release was extended up to 8 to 12 hrs releasing 86% of the total drug from the microspheres.

Keywords: Aceclofenac, Omeprazole, Solvent-evaporation method, Microspheres.