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Abstract

Development and Characterization of Transdermal patches of Propanalol Hydrochloride for the prophylaxis of Migraine

Nidhi Jain1*, Surendra Dangi 2, Rohit Jain1

1 NRI Institute of Pharmaceutical Sciences, Bhopal, M.P
2 School of Pharmacy and Research, Peoples University, Bhopal, M.P

ABSTRACT

The purpose of the research work to developed to developed transdermal system containing drug propanolol HCl for prophylaxis of migrane with different ratio of polymers like Ethylecellulose (EC), Polyvinyl Pryrrolidone (PVP) and Polyvinyl alcohol (PVA) by the solvent evaporation technique. The formulated trandermal patches were evaluated with thickness, moisture uptake, tensile strength, percent elongation, folding endurance, drug content and weight variation test. All prepared formulation indicated good physical stability. Invitro permeation study was performed in franz diffusion cell. The formulation Propaderma (PVA:PVP;2:1) showed best in-vitro skin permeation through rat skin (Wister alibino rat) as compare to other formulation. The results followed in kinetic profile. The release profile of formulation F1 (r2 = 0.990 for higuchi) indicated that the permeation of drug from the patches was governed by a diffusion mechanism. Hence by going through all the results of study one can deduce there is infect a scope for this propanalol transdermal patch in market for patients suffering from migraine.

Keywords: Propanolol HCl, transdermal patches, prophylaxis of migrane, in-viro permeation study


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