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Abstract

Formulation and in-vitro Evaluation of Mefanemic acid Solid Dispersion

Vipul Jain*, Sukhwant Singh, Jitendra Banveer

Sagar Institute of Research Technology and Pharmacy, Bhopal, M.P

ABSTRACT

The objective of the research work to enhance the solubility of mefanemic acid by formulating solid dispersion with hydrophilic polymers such as poly ethylene glycol (PEG 4000) and ethyl cellulose as carrier and solid dispersions were prepared by the method of conventional and physical mixture technique. Further formulated as tablet and capsular dosage forms and were evaluated for drug content, Invitro dissolution studies and differential scanning calorimetry. Results showed that formulations F1-F5 varied from 58.41-96.91% of drug content, release 20-70% of drug in 60 minutes and follows Hixson crowell dissolution release kinetics. DSC Studies shows that there is no evidence of interaction between drug-excipient and as the solid dispersion exhibited no endothermic peak. During the stability study it was found that at low temperature the capsule shell breakdown and does not able to maintain its physical integrity and at high temperature and RH conditions therefore storage preferably below 300C will make stable formulations.

Keywords: Solubility enhancement, poly ethylene glycol, solid dispersions, differential scanning calorimetry, Hixsoncrowell.


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