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Abstract

Formulation & Characterization of Chitosan based Nanoparticles of an Antidiabetic drug (Voglibose)

*Shweta Dwivedi1, Alok Mahor1, Sunil kumar Prajapati1, Vinod Kumar Dhote2

1Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

2Truba Institute of pharmacy, Bhopal (M.P)

ABSTRACT

The aim of the present research is to develop novel drug delivery system as nanoparticles of a drug meant for lowering post-prandial blood glucose levels in people with diabetes mellitus using Volgibose. Voglibose Loaded Chitosan Nanoparticles as active pharmaceutical ingredient with varying concentration of polymer (chitosan), Poloxamer 188 were obtained successfully using evaporation (single emulsion) technique. These formulations were optimized for various parameters like stirring speed and stabilizer studied etc then characterize for particle size, product yield, drug loading efficiency and physical characterization. Scanning electron microscopy (SEM) images showed the nanoparticles were in size range of 330 to 651 nm and the distribution of particle sizes are found to be monodispersed as the polydispersity index lies below 0 to 1 (0.234 to 0.780) in all the formulations.The physical characterization showed that nanoparticles formulation coded by NP6 showed a better loading efficiency and production yield. The in vitro study showed the slow release of the drug from the nanoparticles and improved permeability compared with pure drug. From the various release kinetic models the formulation NP6 obey the zero order and first order kinetics, followed by diffusion and erosion mechanism. Formulation NP6 showed stable formulation containing drug content of 96.05% studied for 6 months.

Keywords: Telmisartan Nanoparticles; diabetes mellitus; Scanning electron microscopy; polydispersity index.


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