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Abstract

Formulation and Evaluation of Transdermal patches of Maloxicam using Solvent Casting Technique

Shikha Soni1, Neha jain1, Tripti Shukla1, Neeraj Upmanyu1, Subhendu Mishra2

1 School of Pharmacy and Research, Peoples University, Bhopal, M.P
2 Sapience Bioanalytical Research Laboratories, Indrapuri, Bhopal, M.P

ABSTRACT

The purpose of the research work to formulate and evaluate transdermal patches of maloxicam polymers containing drug by solvent casting method. Transdemal patches were prepared with different ratios of combination of polymers like Pectin, Ethyl cellulose and PVP. The prepared patches were evaluated for different physicochemical evaluations like thickness, drug content, moisture uptake, folding endurance, moisture loss and in-vitro diffusion. in-vitro diffusion study is to show the release rates and extent of drug release from dosage form. The cumulative percentage of drug released was found to be the highest (99.29%) from formulation M-2. The Higuchi’s plot has shown the regression value (r2) of 0.995, which indicated that diffusion mechanism, is influencing the drug release. In order to confirm this fact, Peppa’s plot was drawn which has shown a slope value of 0.690, which confirms that the diffusion mechanism is involved in the drug release was of non–fickian diffusion type. Hence formulation M-2 was selected as the optimised formulation by virtue of its drug release kinetics.

Keywords: Meloxicam, Transdermal Patches, Ethyl Cellulose, Pectin, PVP.


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