Formulation and Evaluation of Directly Compressible Agglomerates of Telmisartan
Ripu Daman Verma*, Jitendra Banweer, Praveen Tahilani, Gaurav Goyanar
Sagar Institute of Research Technology & Science- Pharmacy (SIRTS-P), Bhopal (M.P.)
ABSTRACT
The present work is aimed to formulate spherical agglomerates and enhance the micromeritic properties, solubility and dissolution rate of Telmisartan, a poorly water soluble anti-hypertensive drug. The poor water solubility and poor micromeritic properties of telmisartan lead to low dissolution rate and poor flow during tableting. Telmisartan spherical agglomerates were prepared by spherical agglomeration techniques using
a quasi emulsion solvent diffusion method consisting of chloroform and water as good solvent and bad solvent respectively. PVP K30 and PEG 6000 in different concentration were used as hydrophilic polymers in agglomeration process. The effects of drug to excipient ratio, stirring time, temperature and stirring speed on the physical characteristics of
agglomerates were investigated. The agglomerates were characterized to various physicochemical evaluations such as practical yield, drug content, particle size, IR spectroscopy, scanning electron microscopy,
micromeritic properties, solubility and dissolution studies.Tablets were prepared using spherical agglomerates by direct compression and evaluated for tablet properties. Dissolution profiles of the directly compressed tablets of spherical agglomerates were compared with conventional tablets.
Keywords: Telmisartan, Spherical agglomeration, Micromeritic properties, solubility and dissolution rate.
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