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Abstract

Formulation & Development of Amlexanox Loaded Oral Dispersible Tablets For Management of Aphthous Ulcers

*Vinod Dhote1, KanikaDhote2, Dinesh Kumar Mishra3, Subendhu Mishra2

1Truba Institute of pharmacy, Bhopal-462038 (M.P)
2Ravishankar College of Pharmacy, Bhopal-462038 (M.P)
3College of Pharmacy, IPS Academy Indore-452012 (M.P)

ABSTRACT

Amlexanox is the active ingredient in a common topical treatment for recurrent aphthous ulcers of the mouth (canker sores), reducing both healing time and pain. The aim of the present research is to develop oral dispersible tablet dosage form of a drug meant for management of aphthous ulcers of the mouth (canker sores) to allow the administration of the dosage form without water. For formulation of oral dispersible tablets, molecular dispersion granulation technique was employed to optimize the formulation. Formulations are characterize for various parameters like weight variation, hardness, friability, fineness of dispersion, disintegration time and dissolution were evaluated during manufacturing and found satisfactory with meeting the pharamacopoeial limits. Finalized formulation was packed in to blisters and studied for stability at 400C/75%RH. Main physical and chemical quality parameters were evaluated during stability and found satisfactory and within the limits.

Keywords: Amlexanox; aphthous ulcers; Molecular dispersion; oral dispersible tablets; Stability studies.


[Full Text Article]