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Formulation and Evaluation of Microspheres of Rabeprazole Sodium for the Treatment of GERD

Anuj Kumar Patkar1, Sailesh Narayan1, Subhendu Mishra2

1 Depatment of Pharmaceutics, Sagar Institute of Pharmacy and Technology, Bhopal, M.P

2 Sapience Bioanalytical Research Lab, Indrapuri, Bhopal, M.P


The objective of the work was to design multiple unit dosage form as microspheres of a drug meant for management of GERD disorder. Microspheres of Rabeprazole was obtained utilizing orifice ionic gelation technique using HPMC and sodium aliginate as a polymer with various ratios. The results of the density of bulkiness and density of tapping were mentioned in table. Bulkiness values were lies in 0.297 to 0.542 g/cm3 and density of tapping values lies in 0.508 to 0.654 g/cm3 i.e. less than 1.2, indicates good packing. The values of Average particle size and angle of repose were lies in between 291.46 ±8.3 to 432.62 ±7.3, and 250-12’ to 300-20’, respectively indicates acceptable particle size, flow property and also good packing ability. Best % yield was obtained for batch F6 - 96.47 %. Overall % recovery of microspheres obtained > 82%. The drug content of overall formulation we gave >84 % drug content. This batch gave 92.30 %, other formulations gave little bit drug loading than this batch. The invitro release studies formulations (F1, F2, F3) showed Rabeprazole sodium discharge speed in series of 91-94% when compared (F4, F5 and F6) demonstrated a Rabeprazole sodium discharge speed from 86-93% up to duration of 12 hours. From above formulation F1 indicates the better results than other prepared batchs. As formulation F6 shown 97.78% cumulative drug release pattern, this was according to the Acceptance Table of Test 2 given in USP-NF 2007 time duration of 12 hrs.

Keywords: Microsphere, Rabeprazole sodium, GERD, Invito release, HPMC and sodium alginate.

[Full Text Article]