Login

Journal Front Page

News & Events

  • Call for article for April 2024 issue
  • Submissions of Review, Research Article, Short Communication and Case study are being accepted for the current and future issues before 15 March, 2024 of this journal by online process or editor@ajper.com, or ajper.editor@gmail.com. Further information can be found at www.ajper.com.
  • January 2024 Issue published
  • Dear Researcher, It Pleased to inform you that, Asian Journal of Pharmaceutical Education and Research, has successfully launch Volume 13, Issue 1 (January 2024) Issue). You can find the article on http://ajper.com/current_issue.php Article also invited for the Next coming Issue from your side. For More details Visit: www.ajper.com
  • Application For Reviewer
  • We are now going to reconstitute our editorial board members of Reviewer. Please send your resume at ajper.editor@gmail.com and be a part of the editorial board member as Reviewer.
  • AJPER Impact facor
  • It is to pleasure that Ajper SJIF imact facor has increse from 5.019 to 7.014. Also global impact factor incresed from 0.654 to 0.765.
  • ICV
  • AJPER Rank with Index Copernicus Value 61.10 due to high reputation at International Level

Abstract

DEVELOPMENT & CHARACTERIZATION OF NISOLDIPINE LOADED MICROSPHERES

Vinod Dhote1*, KanikaDhote2, Dinesh Kumar Mishra3, Subhendu Mishra2

1Truba Institute of pharmacy, Bhopal (M.P)

2Ravishankar College of Pharmacy, Bhopal (M.P)

3College of Pharmacy, IPS Academy Indore-452012 (M.P)

ABSTRACT

The aim of the present research is to develop multiple unit dosage form as microspheres of a drug meant for management of hypertension (high blood pressure) using Nisoldipine. In the present study microspheres containing nisoldipine were prepared by Solvent evaporation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and based on these preliminary studies, different batches of microspheres were prepared by altering the drug: polymer ratio and cross-linking with calcium chloride. The size of microspheres was in range of 130-140μm. They were spherical in shape as evidenced by photomicrographs and scanning electron microscopy. The percent drug entrapment was in the range of 86-88 % and they could sustain drug release over a period of 8 hrs.

Keywords: Microspheres, Solvent evaporation method, optical microscopy, in-vitro release


[Full Text Article]