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Abstract

FORMULATION DEVELOPMENT OF MICROBALLOONS FOR THE MANAGEMENT OF HYPERACIDITY USING RANITIDINE HYDROCHLORIDE

Sandeep Yadav*, Jitendra Banweer, N.P.S. Sengar, P.D. Mehta

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal (M.P.) 462041

ABSTRACT

The aim of the present research is to develop multiple unit dosage form as microballoons of a drug meant for management of hyperacidity using ranitidine hydrochloride employing poly vinyl alcohol (PVA) and eudragit RS 100 as polymers by Quasi-emulsion solvent diffusion technique. Different batches of microballoons (F1 to F6) were prepared by varying the polymer ratios. With the increase in eudragit concentration entrapment efficiency were increased which may be due to extended release property of polymer. The formulation F6 was selected as an ideal formulation based on entrapment efficiency and in vitro drug release tests. In vitro drug release was carried out in simulated gastric fluid (50ml of 0.1N HCl) for 6h by dialysis technique. The shape of microspheres demonstrated by scanning electron microscopy and found to be spherical. The drug release from the ideal formulation (F6) followed Higuchi model than the zero order kinetic models.

Keywords: Ranitidine hydrochloride, PVA, Eudragit RS 100, scanning electron microscopy.


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