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Abstract
FORMULATION, DEVELOPMENT AND EVALUATION OF OSMOTIC DRUG DELIVERY SYSTEM OF GLIBENCLAMIDE
Nitin Kumar Khare*, Jitendra Banweer, Praveen Tahilani, Gaurav Goyanar
Sagar Institute of Research Technology & Science-Pharmacy, Bhopal (M.P.) 462041
ABSTRACT
The purpose of present research work is to develop osmotic drug delivery of Glibenclamide. Glibenclamide belongs to a class of anti-diabetic (sulfonylurea), It works by Inhibition of ATP-dependent potassium channels. Glibenclamide is selected as model drug to
study the effect of in-situ pore former osmotic capsule because it is an effective anti-diabetic drug. The proposed work is envisaged to carry out the preformulation, optimization, development of in-situ orifice forming osmotic capsule and evaluation of osmotic capsule. In-situ pore forming osmotic capsule of glibenclamide is the one which suit the concept of better patient compliance, delayed release, more efficacies and enough bioavailability to show required pharmacological action and less gastrointestinal side effects. The Glibenclamide osmotic drug delivery system was
successfully developed and evaluated.
Keywords: Osmotic capsule, Glibenclamide, Osmotic pump, Anti-diabetic.
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