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Abstract

FORMULATION AND EVALUATION OF SODIUM ALGINATE AND HPMC MICROBEADS AS A CARRIER FOR THE CONTROLLED RELEASE OF CLONIDINE

Piyush Paliwal*, Jitendra Banweer, N.P.S. Sengar, P.D. Mehta

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal (M.P.) 462041

ABSTRACT

Clonidine Hydrochloride a centrally acting sympatholytic and Imidazoline-derivative hypotensive agent; selective α2-adrenergic agonist. It stimulates alpha2-adrenergic receptors in the brainstem to decrease sympathetic nervous system outflow. It is also administered epidurally to treat pain. The objective of the work was to design multiple unit dosage form as microbeads of a drug meant for management of anxiety and hypertensive disorder. Microbeads offers numerous advantages for releasing one of the drugs or part of the same drug immediately while remaining drug or parts of the same can be sustained release. Microbeads of Clonidine Hydrochloride obtained utilizing orifice ionic gelation technique using HPMC and sodium aliginate as a polymer with various ratios. Prepared beads were evaluated for drug entrapment, drug content, in-vitro release, release kinetic and stability study. particle size of optimized beads was determined by SEM.

Keywords: Clonidine, microbeads, HPMC, sodium alginate, ionic gelation technique.


[Full Text Article]