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Abstract

FORMULATION & EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF SIMVASTATIN USING SYNTHETIC POLYMERS

Triveni Barange*, Praveen Tahilani, Jitendra Banweer

Sagar Institute of Research Technology & Science-Pharmacy, Bhopal (M.P.) 462041

ABSTRACT

In the present research to formulate sustained release matrix tablet of simvastatin. This study examined the release of Simvastatin from polymer matrices PVP K-30 and PEG 4000 separately. Simvastatin is a antihyperlipidemic drug and short half life (t1/2) and usually oral dose regimen (5 to 40 mg) taken to 4 times a day. Sistained release matrix tablet of simvastatin were prepared using PEG 4000, PVP K-30 and microcrystalline cellulose by using by direct compression technique. The tablets were evaluated for physical parameters like thickness, hardness, friability, weight variation, and in vitro release studies. The maximum drug release was found to be 98.59 % over a period of 24 hours in PEG 4000 based tablets as compare to PEG 4000 and PVP K-30. All the formulations were stored at 450±20C, 75 ± 5% RH and subjected to stability studies up to 45 days. It showed that all the formulations are physically and chemically stable.

Keywords: Sustained release, Simvastatin, Direct compression Technique.


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