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Abstract

DENDRIMER: NOVEL STRATEGIES FOR DRUG DELIVERY SYSTEM

Vinod Dhote1*, KanikaDhote2, Dinesh Kumar Mishra3, Subhendu Mishra2

1Truba Institute of pharmacy, Bhopal (M.P)

2Ravishankar College of Pharmacy, Bhopal (M.P)

3College of Pharmacy, IPS Academy Indore-452012 (M.P)

ABSTRACT

The development of novel particulate systems with defined shapes and sizes is of prominent interest in certain therapeutic applications such as drug delivery, gene transfection, diagnostic and imaging. On controlling and designing optimized architectural design of dendrimers; their shape, size, branching pattern length/density, and their surface functionality, clearly discriminate these structures as inimitable and optimal hauler in those applications. Moderately modified dendrimers have been shown to act as nano-drugs adjacent to tumors, viruses and bacteria. Recent triumph in simplifying and optimizing the production of dendrimers make available a large variety of structures while simultaneously reducing the cost of their production. The reflections on biomedical applications of dendrimers given in this review clearly make obvious the impending of this new fourth major class of polymer structural design and undeniably prove the high expectation for the future of dendrimers.

Keywords: Novel particulate systems, Dendrimers, gene transfection.


[Full Text Article]