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Abstract

PROTECTIVE EFFECT OF PHENOLIC EXTRACT OF CUCURBITA PEPO SEEDS IN NEUROPATHIC PAIN MODELS

Nasreen S. Chaudhary1, Rachana D. Sarawade 2

1Student, Dr L H Hiranandani College of Pharmacy, Pharmacology Department
,Ulhasnagar-03
2Assistant professor/H.O.D in Dr L H Hiranandani college of pharmacy, Pharmacology department ,Ulhasnagar-03.

ABSTRACT

Neuropathic pain arising from peripheral nerve injury is a clinical disorder characterized by a combination of spontaneous pain, hyperalgesia and tactile pain (allodynia), and remains a significant clinical problem. It is a complex clinical syndrome which affects large number of population in the world, has a massive cost for the health care system and is personally devastating to the people who experience it. In the present study the extraction of phenolic compounds from the seeds of Cucurbita pepo was done where vanillin as a phenolic compound is mainly focused in the study which was used for evaluating neuropathic pain management activity using pyridoxine induced neuropathic pain and alcohol induced neuropathic pain models. The main objective was to explore the analgesic activity of extract by checking the tail flick latency and inclined screen performances of rats in pyridoxine induced model and also to determine the antioxidant activity of extract by estimation of TBARSs and glutathione assay in sciatic nerves of alcohol induced neuropathy in rats. It was found that phenolic extract of c.pepo seeds showed a significant antineuropathic pain activity.

Keywords: Neuropathic pain, hyperalgesia, allodynia, Cucurbita pepo, phenolic extract, antioxidant activity.


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