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Abstract

Formulation and Development of Transdermal Drug Delivery Anti-Rheumatic Ayurvedic Principles

Vinod Kumar Dhote, Kanika Dhote

Truba Institute of Pharmacy, Bhopal (M.P) 462036

ABSTRACT

Rheumatic disorders and chronic inflammatory and degenerative diseases of the musculoskeletal system were chosen in an attempt to discuss remedies described in the old herbals in the viewpoint of modern science. The present investigation was aimed to formulate transdermal films incorporating herbal drug components. The allopathic system of medicine includes two conventional lines of treatment for rheumatoid arthritis, which come along with certain side effects. Hence, turning to safe, effective and time-tested Ayurvedic herbal drug formulation would be a preferable option. With this view transdermal films incorporating herbal drug components such as boswellic acid (Boswellia serrata) and curcumin (Curcuma longa) was envisaged selection based on synergistic action in suppressing inflammation and safety profile. The prepared polymeric films were assessed for their physical properties like percentage flatness, thickness uniformity, and drug content and diffusion studies across hairless mouse skin. The average % release of curcumin was found to be 50.70% and 69.84% for boswellic acid (peak 1) and 64.84% for boswellic acid (peak 2) in the hydroalcoholic diffusion medium at the end of 9 hrs. The graphs obtained for the average per cent release through transdermal film indicate drug release occurred at a constant rate. The skin irritation study done on albino rabbit skin showed that the formulation does not produce irritation to the skin. Taken as a whole, it was observed that the well-known ayurvedic drugs have been found to be effective through modern pharmaceutical formulation techniques.

Keywords: Anti-inflammatory, Transdermal, Ayurvedic herbal drug, curcumin.


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