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Abstract

Nephroprotective activity of nelumbo nucifera gaertn. roots, leaves and flowers on gentamicin induced nephrotoxicity

Toshi Dubey1, Amit Kumar Srivastava2*, Hemant Nagar3, Brajesh Kunwar Mishra1, Subhendu
Sekhar Mishra4

1Technorates Institute of Technology, Bhopal (M.P), India.
2Sapience Bioanalytical Research Lab, Bhopal, (M.P.), India.
3Truba Institute of Pharmacy, Bhopal, (M.P.), India.
4Radharaman College of Pharmacy, Bhopal (M.P.), India.

ABSTRACT

The present study was designed to investigate the nephro-protective effect of ethanolic extract of Nelumbo nucifera Gaertn. leaves flowers and roots on gentamicin induced nephrotoxicity in wistar albino rats. Animals were divided in to five groups i.e. Group I Control, Group II Negative control:recived gentamicin 100mg/kg BW, i.p, O.D. for 12 days, Group III: received roots extract of Nelumbo nucifera, 100mg/kg BW, p.o. + gentamicin 100mg/kg, i.p, O.D. for 12 days, Group IV: received flowers extract of Nelumbo nucifera, 100mg/kg BW,p.o. + gentamicin 100mg/kg, i.p, O.D. for 12 days, Group V: received leaves extract of Nelumbo nucifera, 100mg/kg BW, p.o. + gentamicin 100mg/kg, i.p, O.D. for 12 days. As gentamicin associated nephrotoxicity involves the generation of free radicals via oxidative stress, in vitro antioxidant activity and free radical scavenging activity of different extracts was also performed. Effect of concurrent administration of various extracts of Nelumbo nucifeara was determined by assessing the change in body weight of animals, urine volume, analyzing the various biochemical parameters e.g. urine and serum creatinine, urea and uric acid as the marker of glomerular damage and histopathological findings. Overall results of this study suggested that roots extract of Nelumbo nucifera protects kidney damage caused by gentamicin induced Nephrotoxicity effectively by decreasing the biochemical urine and serum marker enzymes like creatinine, urea and uric acid. The histopathological studies of the kidney revealed a protective role of roots extract of Nelumbo nucifera in gentamicin treated animals. The results exhibited that the pretreatment with ethanolic extract of roots of Nelumbo nucifera may be useful in preventing the kidney damage induced by gentamicin in experimental animals.

Keywords: Nephrotoxicity, Antioxidant, Gentamicin, Nelumbo nucifera


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