Enhancement of Oral Bioavaibility of Irbesartan by Niosomal Formulation
Niharika Thakur1, Piush Khare1, Azad Khan2, Amit Kumar Srivastava*3
1Truba Institute of Pharmacy, Bhopal, (M.P.), India.
2ITS Paramedical (Pharmacy) College, Muradnagar Ghaziabad, (U.P.), India.
3Sapience Bioanalytical Research Lab, Bhopal, (M.P.), India.
The purpose of this research was to prepare the Irbesartan niosome in a trial to improve its oral bioavaibility. Niosome are vesicles mainly consisting of nonionic surfactant. These NSVs were prepared by the conventional film hydration method. The mixture consisted of cholesterol, span-80 & chloroform in the molar ratio 65:60:5 respectively. The entrapment ~10% of Irbesartan used in the hydration, for hydration phosphate buffer pH 7.5 solution was used, the vesicles have an average size of 0.95m, the most probable size of 0.8m and average size range 0.4 to 2.2 m, most of the noisome have unilamellar or spherical shape. The niosomal formulation significantly retard release compared with free drug. The in-vivo study revealed that niosomal dispersion significantly improved oral bioavaibility of Irbesartan in rabbit, after a single oral dose of 40mg/kg. The average relation bioavaibility of the drug from the niosomal dispersion in relation to the free solution was 2.55 indicating more than two folds increase in drug bioavaibility. In conclusion, the niosomal formulation would be an improving delivery system for Irbesartan, with improved bioavaibility and prolonged drug release profiles.
Keywords: Niosome, Oral bioavaibility, Irbesartan.
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