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Fabrication of Chitosan and Poly-Acrylic Acid Complexes as Osmogent for Swellable Nanoporous Osmotic Pump

Manish Balasaheb Phad, Avinash Kondalkar, Priti Tagde,

NRI Institute of Pharmacy, Bhopal


In present study on controlled porosity osmotic tablet of Irbesartan was performed. The study involved two stages, at first stage; optimization of sodium chloride in the core tablet to optimize the release of water insoluble Irbesartan, while the second stage involved the formulation and evaluation of the CPOP (chitosan and poly-Acrylic acid osmotic pump) and study effect of different concentrations of swelling polymer (chitosan and carbopol 934 P). Irbesartan is a angiotensin II given in the treatment of hyprtension. Irbesartan is water insoluble drug so by optimization of sodium chloride in the core tablet, concentration of chitosan and carbopol 934 P in the proper weight ratios modifies the release of water insoluble Irbesartan in order to make it controlled release approach for 10 hrs.. The study reveals successful performance of optimization technique for the development of controlled porosity osmotic tablet drug delivery. When the release rate of osmotic tablets, it was found that increse3 in concentration of chitosan and carbopol 934P, the drug release was found to be increased.

Keywords: Osmotic Tablet, Chitosan, Carbopol 934P

[Full Text Article]