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Abstract
BRIEF OVERVIEW ON ALZHEIMER`S DISEASE WITH RECENT TREATMENT
Pathak Divya
Kunal College of Pharmacy,Agra,Uttar Pradesh,India
ABSTRACT
The pathophysiology of Alzheimer Disease is very complexes, involving neurotransmitter system and processes. In this review number of diversity of aberrant mechanism increase the hope of finding and diverse therapeutic intervention for the treatment of AD. Hallmarks of AD neuritic plaque, loss of cholinergic cells, tau protein. It is the most common cause of dementia, leading to deterioration in vital cognitive process and behavioural changes. There are five drug approved for AD i.e. Acetylcholinesterase inhibitors (4), for the symptoms of mild to moderate AD and glutamate receptor antagonist (1),for the treatment of moderate to severe AD. Recent developments in the field confirm some important predictions of the hypothesis and shed new lights on potential mechanisms regarding how steady state may be achieved in severe or sporadic AD cases ,our opinion is that, strengthen the hypothesis & our studied with these drugs are focusing on longer effect or follow up.
Keywords: Amyloid protein, neurofibrillary tangent, Acetylcholine, Alzheimer, APOE.
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